منابع مشابه
Protein O-glycosylation analysis.
This review provides an overview on the methods available for analysis of O-glycosylation. Three major themes are addressed: analysis of released O-glycans including different O-glycan liberation, derivatization, and detection methods; analysis of formerly O-glycosylated peptides yielding information on O-glycan attachment sites; analysis of O-glycopeptides, representing by far the most informa...
متن کاملMucin-Type O-Glycosylation in Gastric Carcinogenesis
Mucin-type O-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. Modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their glycan products constitute well-established molecular hallmarks of disease state. This review addresses the major role played by mucins and asso...
متن کاملO-Glycosylation of Nuclear and Cytosolic Proteins
1Graduate Program, Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294 2Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205-2185 §To whom correspondence should be addressed. * The authors’ work was supported by NIH Grants HD 13563 and CA 42486 as well as grants ...
متن کاملMucin-Type O-Glycosylation in Invertebrates.
O-Glycosylation is one of the most important posttranslational modifications of proteins. It takes part in protein conformation, protein sorting, developmental processes and the modulation of enzymatic activities. In vertebrates, the basics of the biosynthetic pathway of O-glycans are already well understood. However, the regulation of the processes and the molecular aspects of defects, especia...
متن کاملO-Linked glycosylation in Acanthamoeba polyphaga mimivirus.
Acanthamoeba polyphaga mimivirus is a member of the giant nucleocytoplasmic large DNA viruses, infecting various Acanthamoeba spp. The genomes of giant viruses encode components previously thought to be exclusive to cellular life, such as proteins involved in nucleic acid and protein synthesis. Recent work on enzymes involved in carbohydrate biosynthesis and metabolism show that instead of util...
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ژورنال
عنوان ژورنال: Medical Mycology
سال: 2001
ISSN: 1369-3786,1460-2709
DOI: 10.1080/mmy.39.1.67.74